The Neuroimaging ReasonIng Copilot (NeuRIC) is an advanced AI system designed to support the comprehensive differential diagnosis of neurological disorders through transparent, traceable, and clinically aligned reasoning. While modern deep-learning models demonstrate strong performance in medical imaging, they often lack interpretable evidence and stepwise logic—elements that are essential for clinical trust, accountability, and safe deployment in real-world workflows.

NeuRIC addresses these critical gaps by generating professional, interpretable, and step-by-step reasoning chains that mirror physicians’ cognitive processes. Leveraging this structured reasoning framework, NeuRIC delivers state-of-the-art standalone diagnostic accuracy across diverse datasets, ranging from prospective internal cohorts to multi-center international populations.

Beyond diagnostic performance, NeuRIC functions as a clinical copilot, substantially enhancing clinicians’ accuracy, confidence, and efficiency. By providing transparent and traceable reasoning evidence, NeuRIC not only improves decision quality but also fosters deeper clinician trust, reduces human bias, and encourages more effective human–AI collaboration.